Weird one here. Had a user Tiffany@domain.com who has left for extended leave, and a fellow has taken over her duties. Meanwhile their office is also switching over to role-based email addresses, so I changed the user name from Tiffany Pink to Joe Smith, and the email address from tiffany@domain.com to nothingmanager@domain.com.
I tested sending to and from the newly updated account using my own personal email, worked fine. Then a few days later I got an email from Joe saying that 1 employee in accounting and 1 employee in another department can't email him, and the bounce message is:
#550 5.1.1 RESOLVER.ADR.ExRecipNotFound;
Which suggests the user doesn't exist, but me and everyone else can email him. I cleaned the autocomplete cache on the accounting computer but still same message. The Exchange troubleshooting assistant thinks...