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Requested #550 Denied by policy ##

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When ever I try to send a message to one particular address I get this instant bounce back

Requested rejected your message to the following e-mail addresses:

outsidevendor@somewhere.com

Requested gave this error:
Denied by policy

A problem occurred during the delivery of this message to this e-mail address. Try sending this message again. If the problem continues, please contact your helpdesk.

Diagnostic information for administrators:

Generating server: myserver.main.com

outsidevendor@something.com
Requested #550 Denied by policy ##

Original message headers:

Received: from myserver.main.com([fe80::6894:24a2:364:935d]) by myserver.main.com

 ([fe80::6894:24a2:364:935d%12]) with mapi id 14.02.0387.000; Mon, 7 Apr 2014
 10:56:29 -0700
From: me <me@somewhere.com>
To: "outsidevendor@somwhere.com"

Subject: RE: printing
Thread-Topic: printing
Thread-Index: Ac9ShtXYIlGhALgvRR66mu72RBxupQAADXAQAABo4gAAAH9l8A==
Date: Mon, 7 Apr 2014 17:56:29 +0000
Message-ID: <5A187948AB107A4896D1E2CBEA5289695B80E5B1@
myserver.main.com>

Accept-Language: en-US
Content-Language: en-US
X-MS-Has-Attach: yes
X-MS-TNEF-Correlator:
x-originating-ip: [192.168.3.94]
Content-Type: multipart/related;
            boundary="_004_5A187948AB107A4896D1E2CBEA5289695B80E5B1myserver_";
            type="multipart/alternative"
MIME-Version: 1.0

The server is an exchange 2010 box and has been up for 3 years without ever seeing this issue. The only spam filtering I am using is the GFI mail essentials product. The email address has been the only one that this has ever happened to and was added to the GFI whitelist.

Anyone ever see this before?

Thanks

Sean


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