Hack attempt through Exchange - Event ID 4625

I am getting repeated Event ID 4625 - Audit Failures on my Exchange server:

An account failed to log on.

Subject:
    Security ID:        NETWORK SERVICE
    Account Name:        EXCHANGE2$
    Account Domain:        xxxx
    Logon ID:        0x3e4

Logon Type:            8

Account For Which Logon Failed:
    Security ID:        NULL SID
    Account Name:        backupexec
    Account Domain:       

Failure Information:
    Failure Reason:        Unknown user name or bad password.
    Status:            0xc000006d
    Sub Status:        0xc0000064

Process Information:
    Caller Process ID:    0xdb8
    Caller Process Name:    C:\Program Files\Microsoft\Exchange Server\V14\Bin\EdgeTransport.exe

Network Information:
    Workstation Name:    EXCHANGE2
    Source Network Address:    -
    Source Port:        -

Detailed Authentication Information:
    Logon Process:        Advapi 
    Authentication Package:    MICROSOFT_AUTHENTICATION_PACKAGE_V1_0
    Transited Services:    -
    Package Name (NTLM only):    -
    Key Length:        0

They'll cycle through with names like Admin, Administrator, BackupExec, etc.  I have thousands of them. 

While they don't appear to be even close to gaining access, they're wasting bandwidth and cpu cycles.  I don't see anywhere to get the IP they're coming from to block it.  Any quick way to shut this down?

Thanks for any advice.